Bionfo

The Bioinfo division came up from the need to create softwares compatible with the medical diagnostic field. Inside our group we have a highly capacited IT personnel that, in partnership with companies specialized in softwares, have developed and continue developing programs to help us with our routines and our results.


According to this tendency, Centro de Genomas® has just initiated an international partnership with TherapyEdge®, a company with long clinical experience in the area of information technology that offers health professionals intelligent systems for the control of their patients.


The patent of TherapyEdge®, based on a interface web hosted at a local server, allows the doctor to identify and make the easiest decision regarding a therapy choice for patients having chonic or complex illnesses, using an advanced and intelligent technology to evaluates the last medication available and thus offers the best clinical decision, according to national and international references.


TherapyEdge® also keeps a complete transversal database, which qualifies patient service and identifies the best practice, evaluating the efectiveness through diagnostic tests.


The system of TherapyEdge® works on a web page through the internet, through the local web of the point of care or from the laboratory itself. Thanks to its flexible architecture, it has perfect communication with different systems and allows to integrate into the TherapyEdge® system all relevant data in order to optimize the patient’s process: medication, diagnostic data and therapies.


TherapyEdge® evaluates the patient’s state and generates various choice options between the most recent and advanced therapies, showing clinical data (including all service progress performed by the doctor, nurses, etc) and laboratory data through graphics that include efectiveness and response indictors, resistence to medication and trustful laboratory results in an integrated data bank.


Also regarding systems related to the interpretation of Molecular Medicine data, there is na increasing need for the development of an informatics able to calculate automatically the paternity indices and probabilities for two or three people involved in the test.Centro de Genomas® makes its own software, the SIP - Sistema de Investigação de Paternidade available for clients who possess a DNA sequencer and need to automatize their calculations, as well as generate their results automatically.


Our objective is to use the software for na automatized calculation of the combined index and paternity probability for parental investigation tests in cases where the alledged father’s genetic material is not available, thus making it possible for the result to be quicker and more accurate.


Presently, some genetic laboratories already possess automatized systems for the calculation of individual indices, accumulated index and parental probability, which are included in the findings for the cases where the alledged father’s, the mother’s and the son’s DNA is available. However, it is very useful to have a computer software for the automatized calculation in the cases of genetic reconstruction, i. e., when the alledged father’s DNA material is not available (for instance when he is deceased). In those cases, genetic profiles obtained through the analysis of the DNA coming from the alledged father’s relatives (relatives in the legitimate descending, ascending or collateral line) are compared to the son’s and mother’s (if available) profiles, and by using some rules it is possible, in some cases, to reconstruct the alledged father’s profile and issue a conclusion with satisfactory inclusion index, in order to fulfil the demands of a lawsuit. This kind of software is very rare in the market place.


Sometimes, the number of individuals studied is too large, which makes it difficult to establish a genetic vinculation. The usage of our software doen not only aim at speeding up the calculation process, but also significantly reduce human mistakes through automatizing processes which previously used to be operated (typing of results, index calculations, result assembly). In this way, through automatized routines for the identification of sample manipulation flaws, our system checks the possible sample changes, duplications or contaminations by PCR products.